Updated Monkeypox Vaccination and Antiviral Guidance

Advisory Alert

September 1, 2022

*Cette information est seulement disponible en anglais.

To: Local Health System Partners


Stay up to date with Monkeypox vaccination and treatment guidance and other key resources by visiting the Ministry of Health website

Imvamune® is the approved vaccine in Canada that is used as pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) for monkeypox. Current Ontario guidelines recommend using a single dose of the vaccine as PrEP to limit ongoing transmission of monkeypox. Two doses are recommended as PrEP for moderately to severely immunocomprimised individuals and certain laboratory employees. For the full definition and list of moderately to severely immunocompromised individuals, please consult Appendix A of the Ministry of Health’s Monkeypox Vaccine (Imvamune®) Guidance for Health Care Providers. See Appendix B of this document for guidance on how to verify second dose eligibility for moderately to severely immunocompromised individuals.

Further information on the use of Imvamune® in special populations has been provided:

Please refer to Monkeypox Vaccine (Imvamune®) Guidance for Health Care Providers for details regarding all special populations including:

If you are providing support to an individual who is under 18 years of age and has had high or intermediate risk monkeypox exposure, please consult a local pediatrician for clinical advice regarding Imvamune® administration.

Eligible individuals seeking PrEP should be directed to call Public Health at 705.522.9200, ext. 482 (toll-free 1.866.522.9200) or Réseau ACCESS Network at 705.688.0500. Individuals can also call Public Health at ext. 772 if they are seeking PEP.

Tecovirimat (TPoxx®), the antiviral medication used to treat monkeypox in Canada, can be requested to the Ministry of Health’s Emergency Operations Centre (MEOC) at EOCoperations.MOH@ontario.ca or by calling the Healthcare Provider Hotline at 1-866-212-2272. When requesting TPoxx®, clinicians must provide specific information for each patient that has consented to treatment, as outlined in Appendix A of the Ministry of Health’s Monkeypox Antiviral Guidance for Health Care Providers.

Additional Resources

For guidance on preventing monkeypox transmission in health care settings, please see Public Health Ontario’s (PHO) Infection Prevention and Control (IPAC) Recommendations for Monkeypox in Health Care Settings. Additional monkeypox resources can be found on PHO’s website.

For case and contact management information, please contact the Control of Infectious Diseases program at 705.522.9200, ext. 772 (toll-free 1.866.522.9200).


Original Signed By

Dr. Penny Sutcliffe
Medical Officer of Health and Chief Executive Officer

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This item was last modified on April 2, 2024